Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
From linear questionnaires to computer-adaptive tests: Content development and calibration of the Digital Eye Strain Computer Adaptive Test (DESCAT) [PDF]
We published in 2015 a linear Rasch-based scale (Computer Vision Symptom Scale, aka CVSS17) for measuring the computer-related visual and ocular symptoms in workers using video-display terminals.
Barrio De Santos, Ana Rosa +3 more
core
One of the major consequences of the digital revolution has been the increase in the use of electronic devices in health services. Despite their remarkable advantages, though, the use of computers and other visual display terminals for a prolonged time ...
Eva María Artime Ríos +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Usability of digital libraries: a study based on the areas of information Science and Human-Computer Interaction [PDF]
The conception, planning and implementation of digital libraries, in any area of knowledge, demand innumerable studies in order to verify and guarantee their adequacy to the users’ necessities. Such studies find methodological, conceptual and theoretical
Ferreira, Sueli Mara +1 more
core
Conformal mapping for multiple terminals [PDF]
: Conformal mapping is an important mathematical tool that can be used to solve various physical and engineering problems in many fields, including electrostatics, fluid mechanics, classical mechanics, and transformation optics.
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Access to the energy system network simulator (ESNS), via remote computer terminals. [BNL CDC 7600/6600 computer facility] [PDF]
The Energy System Network Simulator (ESNS) flow model is installed on the Brookhaven National Laboratory (BNL) CDC 7600/6600 computer facility for access by off-site users.
Reisman, A W
core +1 more source
Correction: In the publication, the study period was missed. The study period "from 2nd April 2018 to 15th April 2018" has been added. Introduction: Computers and other visual display terminals are now an essential part of our daily life.
Anjila Basnet +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source

