Results 211 to 220 of about 31,190 (275)

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

open access: yesMovement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska   +6 more
wiley   +1 more source

Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Genetic mitochondrial diseases (GMDs) are a large group of genetically and clinically heterogeneous disorders caused by defects in genes encoding mitochondrial components. GMDs are grouped into named syndromes based on clinical presentation, for example, Leigh syndrome (LS).
Brittany M. Johnson, Simon C. Johnson
wiley   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

open access: yesPediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil   +2 more
wiley   +1 more source

The transformative potential of artificial intelligence in pediatric medicine: Current applications, methodological challenges, and future directions

open access: yesPediatric Investigation, EarlyView.
Artificial intelligence (AI) offers transformative potential for paediatric diagnosis and treatment, yet implementation faces unique challenges, including data scarcity, algorithmic bias, and children's developmental physiology. This review examines current applications and charts a path toward transparent, equitable, and trustworthy AI in child health.
Ruisong Wang   +3 more
wiley   +1 more source

Epistemic diversity and the politics of knowledge in plant disease management: Insights from the Xylella fastidiosa epidemic in southern Italy

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Xylella fastidiosa is a major plant pathogen affecting crops such as grapes, citrus, almonds, and olives, with potentially severe consequences for agricultural production and rural livelihoods worldwide. This paper examines the conflict around the management of the X. fastidiosa outbreak affecting olive trees in southern Italy.
Fabio Gatti   +2 more
wiley   +1 more source

Machine Learning‐Guided Near‐Infrared Laser Processing for Precise Geometry Control in Microneedles with Downstream microLED‐Triggered Photothermal Functionality

open access: yesSmall, EarlyView.
Machine learning‐guided near‐infrared laser processing enables predictive fabrication of microneedles with application‐specific geometries. The optimized metal templates are translated into polymeric microneedles and integrated with a flexible microLED platform.
Ismail Eş   +4 more
wiley   +1 more source

Causes, treatment and outcome of external ear canal tears and avulsions in cats and dogs: 24 cases (2008‒2024)

open access: yesVeterinary Record, EarlyView.
Abstract Background This study aimed to evaluate the causes, treatment options and associated complications of ear canal tears and avulsions in dogs and cats. Methods This retrospective clinical study includes 14 cats and 10 dogs diagnosed with external ear canal tears and avulsions using otoscopy and/or computed tomography.
Eva M. Billau, Cetina Thiel
wiley   +1 more source

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