Results 41 to 50 of about 61,527 (308)

Confidence and quality in managing CKD compared with other cardiovascular diseases and diabetes mellitus: a linked study of questionnaire and routine primary care data

BMC Family Practice, 2011
Background Much of chronic disease is managed in primary care and chronic kidney disease (CKD) is a recent addition. We are conducting a cluster randomised study of quality improvement interventions in CKD (QICKD) - Clinical Trials Registration ...
Tahir Mohammad A, Dmitrieva Olga, de Lusignan Simon, van Vlymen Jeremy, Chan Tom, Golmohamad Ramez, Harris Kevin, Tomson Charles, Thomas Nicola, Gallagher Hugh   +9 more
doaj   +1 more source

Opportunities for and challenges of computerisation

The Lancet, 1998
Information technology offers many potential advantages over paper for the storage and retrieval of patients' data. Enthusiasts predict that soon all records will be stored and viewed on computer, but others are more sceptical. The failure of some computer-based records may be due to poor information design.
S M, Powsner, J C, Wyatt, P, Wright
openaire   +2 more sources

Effectiveness of local support for the adoption of a national programme – a descriptive study

Journal of Innovation in Health Informatics, 2014
Background Change management in health care is a complex and time-consuming endeavour, and no less so in implementing technological systems. In deploying a nationwide programme, the personally controlled electronic health record (PCEHR), the Australian ...
Christopher Pearce, Jenny Bartlett, Adam McLeod, Paula Eustace, Rod Amos, Marianne Shearer   +5 more
doaj   +1 more source

Development and Validation of the Computerised Adaptive Beat Alignment Test (CA-BAT)

Scientific Reports, 2018
Beat perception is increasingly being recognised as a fundamental musical ability. A number of psychometric instruments have been developed to assess this ability, but these tests do not take advantage of modern psychometric techniques, and rarely ...
Peter M C Harrison, Daniel Müllensiefen   +1 more
semanticscholar   +1 more source

Computerised interventions designed to reduce potentially inappropriate prescribing in hospitalised older adults: a systematic review and meta-analysis

Age and Ageing, 2018
Background computerised interventions have been suggested as an effective strategy to reduce potentially inappropriate prescribing (PIP) for hospitalised older adults.
K. Dalton, G. O’Brien, D. O’Mahony, S. Byrne   +3 more
semanticscholar   +1 more source

A systematic review of trials evaluating success factors of interventions with computerised clinical decision support

Implementation Science, 2018
BackgroundComputerised clinical decision support (CDS) can potentially better inform decisions, and it can help with the management of information overload. It is perceived to be a key component of a learning health care system.
S. Van de Velde, A. Heselmans, N. Delvaux, L. Brandt, Luis Marco-Ruiz, D. Spitaels, Hanne Cloetens, T. Kortteisto, P. Roshanov, I. Kunnamo, B. Aertgeerts, P. Vandvik, S. Flottorp   +12 more
semanticscholar   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Clinical and cost-effectiveness of computerised cognitive behavioural therapy for depression in primary care: Design of a randomised trial

BMC Public Health, 2008
Background Major depression is a common mental health problem in the general population, associated with a substantial impact on quality of life and societal costs.
Severens Johan L, Riper Heleen, Arntz Arnoud, Evers Silvia MAA, Gerhards Sylvia AH, de Graaf L Esther, Widdershoven Guy, Metsemakers Job FM, Huibers Marcus JH   +8 more
doaj   +1 more source