Results 121 to 130 of about 3,565,684 (300)

Singleton {NOT} and Doubleton {YES; NOT} Gates Act as Functionally Complete Sets in DNA-Integrated Computational Circuits

Nanomaterials
A functionally complete Boolean operator is sufficient for computational circuits of arbitrary complexity. We connected YES (buffer) with NOT (inverter) and two NOT four-way junction (4J) DNA gates to obtain IMPLY and NAND Boolean functions, respectively,
Andrea C. Bardales, Quynh Vo, Dmitry M. Kolpashchikov   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Computers in personnel

, 1991
33.00; Published in association with CIP 91, the 10. National Conf. and Exhibition on Computers in Personnel, held London (GB). 26-27 Jun 1991SIGLEAvailable from British Library Document Supply Centre- DSC:4371.668(IMS-R--207) / BLDSC - British Library ...
Page, T, Institute of Personnel Management (IPM), London (United Kingdom), Institute of Manpower Studies (IMS), Brighton (United Kingdom), Institute of Personnel Management, London (United Kingdom), Institute of Manpower Studies, Brighton (United Kingdom)   +4 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Computers & Culture, Issue 1

, 2023
Computers & Culture is an interdisciplinary digital pamphlet featuring short essays and notes of relevance to the digital and computers in the wider arts, humanities, and social sciences.
MacCarron, Máirín, O'Sullivan, James, del Rio Riande, Gimena, O'Connell, Micheál, Fiormonte, Domenico   +4 more
core  

Mathematics and Computers in Simulation

, 2015
Mathematics and Computers in Simulation Special Issue for the 7th edition of SDS: Structural Dynamical Systems 2012 . Special issue devoted to collect developments in computational and theoretical methods for Dynamical Systems, their numerical ...
Spaletta Giulia
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Fluorescence-Based Multimodal DNA Logic Gates

Nanomaterials
The use of DNA structures in creating multimodal logic gates bears high potential for building molecular devices and computation systems. However, due to the complex designs or complicated working principles, the implementation of DNA logic gates within ...
Chamika Harshani Algama, Jamil Basir, Kalani M. Wijesinghe, Soma Dhakal   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source