Results 91 to 100 of about 4,892,723 (368)
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source
Computability and Non-computability Issues in Amorphous Computing [PDF]
, 2012 Amorphous computing systems consist of a huge set of tiny simple stationary or mobile processors whose computational, communication and sensory part is reduced to an absolute minimum. In an airborne medium the processors communicate via a short-range radio while in a waterborne medium via molecular communication. In some cases the computational part of
openaire +4 more sources
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Bacteria as computers making computers [PDF]
FEMS Microbiology Reviews, 2009 Various efforts to integrate biological knowledge into networks of interactions have produced a lively microbial systems biology. Putting molecular biology and computer sciences in perspective, we review another trend in systems biology, in which recursivity and information replace the usual concepts of differential equations, feedback and feedforward ...
openaire +3 more sources
Journal of Imaging, 2019 In this era of digitization, most hardcopy documents are being transformed into digital formats. In the process of transformation, large quantities of documents are stored and preserved through electronic scanning.
Alaa Sulaiman +2 more
doaj +1 more source
Unconventional Quantum Computing Devices [PDF]
in `Unconventional Models of Computation,' C.S. Calude, J. Casti,
M.J. Dinneen, eds., Springer, Singapore, 1998, 2000 This paper investigates a variety of unconventional quantum computation devices, including fermionic quantum computers and computers that exploit nonlinear quantum mechanics. It is shown that unconventional quantum computing devices can in principle compute some quantities more rapidly than `conventional' quantum computers.
arxiv
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Training and Serving System of Foundation Models: A Comprehensive Survey
IEEE Open Journal of the Computer SocietyFoundation models (e.g., ChatGPT, DALL-E, PengCheng Mind, PanGu-$\Sigma$) have demonstrated extraordinary performance in key technological areas, such as natural language processing and visual recognition, and have become the mainstream trend of ...
Jiahang Zhou +8 more
doaj +1 more source