Results 111 to 120 of about 1,996,524 (318)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Computing News ; vol. 15, no. 04 (Summer 2000) [PDF]

open access: yes, 2000
24 p.Protect Your Email Password -- Dialpad Internet Phone Service -- Wireless Internet Access on Campus -- New Modems, Modem Number -- Fater In-building Campus Networks on the Way -- Computing Center Annex to Open in September -- New Secondaries Join I2
Winslow, Joyce   +1 more
core  

Practical tooling for serverless computing [PDF]

open access: yes, 2017
Cloud applications are increasingly built from a mixture of runtime technologies. Hosted functions and service-oriented web hooks are among the most recent ones which are natively supported by cloud platforms.
Josef Spillner, Spillner, Josef
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Computing News ; vol. 07, no. 03 (January 1992) [PDF]

open access: yes, 1992
4 p.Profiles in Computing -- Adaptive Technology Lab Fills Specialized Computing Needs -- Data Services Lab Debuts -- VMS Password Security Tightens -- EVE Set As Default MAIL Editor -- Solving a VNEWS Posting Problem -- Attention, Mac Users-AppleTalk ...
Winslow, Joyce   +1 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Computing News ; vol. 07, no. 01 (October 1991) [PDF]

open access: yes, 1991
6 p.Get Acquainted With Center Services -- Microcomputer Support Center Services -- Public Domain Libraries -- File Transfer, Virus Clinic, Disk Recovery -- Public LaserWriter -- Microcomputer Resources -- Electronics Shop Repair, Upgrades -- Apple ...
Winslow, Joyce   +1 more
core  

CSC776: Emergent Computing Technologies / College of Computing, Informatics and Media [PDF]

open access: yes, 2022
This course will explore current emergent computing technologies globally and locally to keep the students abreast with the opportunities created by these emergent technologies.
UiTM, College of Computing, Informatics and Media
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

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