An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Basic concepts and taxonomy of dependable and secure computing
IEEE Transactions on Dependable and Secure Computing, 2004 A. Avizienis +3 more
semanticscholar +1 more source
Joint Service Chain Orchestration and Computation Offloading via GNN-Based QMIX in Industrial IoT. [PDF]
Sensors (Basel)Huang X, Tian B.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Review of Embedded Artificial Intelligence Research (2023-2026): Technological Advancements, Representative Advances, and Future Prospects. [PDF]
Micromachines (Basel)Zhang Z.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Performance-Effective and Low-Complexity Task Scheduling for Heterogeneous Computing
IEEE Trans. Parallel Distributed Syst., 2002 H. Topcuoglu, S. Hariri, Minyou Wu
semanticscholar +1 more source
Correction: Application of the cyberinfrastructure production function model to R1 institutions. [PDF]
Front Res Metr AnalSmith PM +5 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Advanced security in fog environments using encryption and adaptive user activity tracking. [PDF]
Sci RepRai HM +5 more
europepmc +1 more source