Results 61 to 70 of about 35,060 (262)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
GPT Models Can Perform Thematic Analysis in Public Health Studies, Akin to Qualitative Researchers
Journal of Social ComputingConducting thematic analysis in qualitative research can be laborious and time-consuming. We propose and evaluate the feasibility of using Generative Pre-trained Transformer (GPT) models to assist public health researchers in extracting themes from ...
Yuyi Yang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
GEOmedia, 2017 Nowadays, the increasing availability of low-cost sensors, Free and Open Source Software and High Performance Computing infrastructures allows Geomatics to widen its application scope, by stimulating new challenging investigations related to the modeling
Roberta Ravanelli +5 more
doaj +2 more sources
On MDA - SOA based Intercloud Interoperability framework [PDF]
Computational Methods in Social Sciences, 2013 Cloud computing has been one of the latest technologies which assures reliable delivery of on - demand computing services over the Internet. Cloud service providers have established geographically distributed data centers and computing resources, which ...
Tahereh Nodehi +3 more
doaj
Dynamic Task Distribution Model for On-Chip Reconfigurable High Speed Computing System
International Journal of Reconfigurable Computing, 2015 Modern embedded systems are being modeled as Reconfigurable High Speed Computing System (RHSCS) where Reconfigurable Hardware, that is, Field Programmable Gate Array (FPGA), and softcore processors configured on FPGA act as computing elements.
Mahendra Vucha, Arvind Rajawat
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Soft Computing Techniques for Dependable Cyber-Physical Systems
IEEE Access, 2019 Cyber-physical systems (CPSs) were envisaged as a way to manipulate the objects in the physical world through computer intelligence. This is usually done by providing a communication bridge between actuation and computing elements.
Muhammad Atif +7 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source