Results 71 to 80 of about 35,060 (262)
Enhancing Education through Leveraging Spatial Computing: A Conceptual Framework
IJIE (Indonesian Journal of Informatics Education)Traditional teaching practices are often characterized by passive learning, limited interactivity, and a lack of real-time contextual feedback, which struggle to meet the evolving expectations of 21st-century learners.
Kudakwashe Maguraushe +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
GeoAI enabled urban computing: status and challenges
Annals of GISGeospatial Artificial Intelligence (GeoAI), an interdisciplinary field integrating geographic information science with artificial intelligence (AI), has emerged as a transformative force in advancing urban computing technologies and applications.
Feng Lu, Shifen Cheng, Peixiao Wang
doaj +1 more source
Introducing the medical bioinformatics in
Journal of Translational Medicine, 2012 The explosion of genome sequencing data along with genotype to phenotype correlation studies has created data deluge in the area of biomedical sciences.
Brahmachari Samir K
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Application of Case-based Methodology for Early Diagnosis of Computer Attacks
Journal of computing and information technology, 2014 In this article we consider the mathematical foundations and software implementation of the early diagnosis of computer attacks. For this we used the JSM method of automatic hypothesis generation and the theory of case-based models.This software outputs hypotheses about the properties and expected consequences of a new computer attack.
Yakhyaeva, Gulnara, Yasinskaya, Olga
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Practical exploration of quantum computational chemistry simulation in the field of batteries
Dianzi Jishu YingyongQuantum computing technology offers acceleration potential for solving practical issues in the field of new energy, particularly in the simulation of complex battery materials.
Zhao Tongge +10 more
doaj +1 more source