Results 41 to 50 of about 90,082,741 (224)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

SA-ConSinGAN and reservoir computing fusion for accurate bearing fault classification and severity identification using GAF-based techniques

Scientific Reports
In the present study, five reservoir computing models are compared and analyzed for bearing fault classification and severity level identification. Three Gramian Angular Field (GAF) methodologies, such as Gramian Angular Summation Field (GASF), Gramian ...
Anjil Shah, Vinay Vakharia, Yogesh Kumar, Marcin Woźniak, Muhammad Fazal Ijaz   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Comprehensive Review of EEG-Based Seizure Detection Techniques

IEEE Access
The automated classification and prediction of epileptic seizures using electroencephalography (EEG) remains a dynamic and critical area of interdisciplinary research, situated at the intersection of neuroscience and computational intelligence.
Goldwyn Sudhakar Jebaraj, Konguvel Elango   +1 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Quantum Overflow Detection for Reliable Bioinspired Image Enhancement

IEEE Access
In quantum information science, fundamental principles of quantum mechanics, particularly quantum parallelism are leveraged to enable computational capabilities that exceed the performance limits of classical computing systems.
Neeraj Kumar Misra, Nirupma Pathak
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Intensity-based gain adaptive unsharp masking for image contrast enhancement

, 2012
With the increasing application of image processing techniques in various areas, contrast enhancement still remains as a core pre-processing element that critically affects the performance of subsequent procedures. Among the available enhancement methods,
Shi, HY, N. M. Kwok, G. Fang, Ha, Quang P., Shi, Haiyan, Kwok, NM, Ha, QP, H. Y. Shi, Fang, G, Fang, Gu (R7659), Q. P. Ha, Kwok, Ngai M.   +11 more
core   +1 more source

Advanced applications in chronic disease monitoring using IoT mobile sensing device data, machine learning algorithms and frame theory: a systematic review

Frontiers in Public Health
The escalating demand for chronic disease management has presented substantial challenges to traditional methods. However, the emergence of Internet of Things (IoT) and artificial intelligence (AI) technologies offers a potential resolution by ...
Yu Liu, Boyuan Wang, Boyuan Wang
doaj   +1 more source