Results 51 to 60 of about 181,536 (234)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Quantum Overflow Detection for Reliable Bioinspired Image Enhancement

open access: yesIEEE Access
In quantum information science, fundamental principles of quantum mechanics, particularly quantum parallelism are leveraged to enable computational capabilities that exceed the performance limits of classical computing systems.
Neeraj Kumar Misra, Nirupma Pathak
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Advanced applications in chronic disease monitoring using IoT mobile sensing device data, machine learning algorithms and frame theory: a systematic review

open access: yesFrontiers in Public Health
The escalating demand for chronic disease management has presented substantial challenges to traditional methods. However, the emergence of Internet of Things (IoT) and artificial intelligence (AI) technologies offers a potential resolution by ...
Yu Liu, Boyuan Wang, Boyuan Wang
doaj   +1 more source

FPGA-based ORB Feature Extraction for Real-Time Visual SLAM

open access: yes, 2017
Simultaneous Localization And Mapping (SLAM) is the problem of constructing or updating a map of an unknown environment while simultaneously keeping track of an agent's location within it.
Fang, Weikang   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Best practices for AI-based image analysis applications in aquatic sciences: The iMagine case study

open access: yesEcological Informatics
The iMagine project is an EU-funded initiative led by the EGI Foundation. One of the objectives of this project is to provide an AI platform that leverages AI-powered tools to improve the processing and analysis of imaging data from marine and freshwater
Elnaz Azmi   +27 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

A Survey on Data Mining for Data-Driven Industrial Assets Maintenance

open access: yesTechnologies
This survey presents a comprehensive review of data-driven approaches for industrial asset maintenance, emphasizing the use of data mining and machine learning techniques, including deep learning, for condition-based and predictive maintenance.
Eduardo Coronel   +2 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

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