Results 41 to 50 of about 108,184 (297)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A hybrid model for decision-making in the information and Communications Technology sector
Technological and Economic Development of Economy, 2015 The majority of businesses in the Information and Communications Technology (ICT) sector face decision-making problems on a daily basis. Most of these problems are based on contexts of uncertainty, where decisions are founded on qualitative information ...
Andrés Cid-López +3 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Towards Rough Datalog : Embedding Rough Sets in Prolog [PDF]
, 2004 Soft computing comprises various paradigms dedicated to approximately solving real-world problems, e.g., in decision making, classification or learning; among these paradigms are fuzzy sets, rough sets, neural networks, and genetic algorithms.It is well ...
Vitoria, Aida,, Maluszynski, Jan,
core
Component-based Segmentation of words from handwritten Arabic text [PDF]
, 2008 Efficient preprocessing is very essential for automatic recognition of handwritten documents. In this paper, techniques on segmenting words in handwritten Arabic text are presented.
Jawad H AlKhateeb +7 more
core +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Efficient computation of absent words in genomic sequences [PDF]
, 2008 Herold J, Kurtz S, Giegerich R. Efficient computation of absent words in genomic sequences. BMC Bioinformatics. 2008;9(1): 167.Background: Analysis of sequence composition is a routine task in genome research.
Kurtz Stefan +8 more
core +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Certain Distance-Based Topological Indices of Parikh Word Representable Graphs
Journal of Mathematics, 2021 Relating graph structures with words which are finite sequences of symbols, Parikh word representable graphs (PWRGs) were introduced. On the other hand, in chemical graph theory, graphs have been associated with molecular structures.
Nobin Thomas +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source