Results 281 to 290 of about 22,612,127 (309)
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Insulinomimetic homology of concanavalin A
Medical Hypotheses, 1983A striking peptide sequence and three dimensional conformational homology between a portion of insulin and the plant lectin concanavalin A is described. This amino acid sequence has been demonstrated to be essential to the bioactivity of the hormone insulin.
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
The reaction of bovine plasma amine oxidase, a glycoprotein, with Concanavalin A in 0.1 M potassium phosphate buffer, pH 7.0 at 25 degrees C were investigated by equilibrium and kinetic methods. A tentative mechanism for the reaction was derived. The Concanavalin A-enzyme interaction was used to show that the carbohydrate is not essential for activity ...
Hiroyuki Ishizaki, Kerry T. Yasunobu
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The reaction of bovine plasma amine oxidase, a glycoprotein, with Concanavalin A in 0.1 M potassium phosphate buffer, pH 7.0 at 25 degrees C were investigated by equilibrium and kinetic methods. A tentative mechanism for the reaction was derived. The Concanavalin A-enzyme interaction was used to show that the carbohydrate is not essential for activity ...
Hiroyuki Ishizaki, Kerry T. Yasunobu
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Structure and Function of Concanavalin A
1975Lectins have been extensively used to analyze a variety of fundamental processes in cell biology. In conjuntion with our studies on the cell surface and mitosis, we have determined the amino acid sequence and three-dimensional struction of concanavalin A (Con A), the mitogenic lectin from the jack bean.
George N. Reeke +5 more
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The concanavalin a binding properties of concanavalin A-resistant and -sensitive hamster cell lines
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1977Abstract The binding of labelled concanavalin A to Chinese hamster ovary cells at 4°C exhibits positive cooperativity. Variant cell lines selected for resistance to the cytotoxic effects of the lectin exhibit altered lectin binding properties.
Jim A. Wright, Howard Ceri
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Immunobiological properties of a concanavalin A derivative
Cellular Immunology, 1978Abstract A monovalent subunit of concanavalin A (Con A) was tested for mitogenic effects on murine splenic lymphocytes in vitro . In contrast to the effects of intact Con A, the monovalent derivative was not mitogenic at any concentration tested. Furthermore, prior exposure of splenic lymphocytes to monovalent Con A rendered the cells refractory to ...
Horowitz, S +3 more
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A Co(III) derivative of concanavalin A
Biochemical and Biophysical Research Communications, 1979Abstract Co(III) has been stoichiometrically incorporated into jack bean concanavalin A. The Co(III) protein still possesses a binding site for an additional divalent transition metal ion which together with Ca(II) can induce the sugar binding ability. No H2O2 oxidation of Co(II) occurs with demetallized concanavalin A activated with Ca(II) and Co(II)
Gerhard R. Munske +4 more
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Adsorption of concanavalin a on human platelets
Annals of Biomedical Engineering, 1982A physiological cell surface adsorption system approach is investigated on human platelets utilizing mathematical modeling. Monodispersed washed platelets are freshly collected in an isotonic buffer as a suspension utilizing a gel filtration technique. Concanavalin A is used as a glycoprotein receptor adsorbate in the adsorption studies.
Anwar B. Bikhazi, Khalil M. Bitar
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Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
Concanavalin A is capable of activating platelets in a concentration-dependent manner as judged by [14C]serotonin secretion from prelabeled platelets. In contrast, succinyl concanavalin A does not induce platelet secretion. Concanavalin A treatment also results in a number of alterations in platelet macromolecules which are presumably associated with ...
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Concanavalin A is capable of activating platelets in a concentration-dependent manner as judged by [14C]serotonin secretion from prelabeled platelets. In contrast, succinyl concanavalin A does not induce platelet secretion. Concanavalin A treatment also results in a number of alterations in platelet macromolecules which are presumably associated with ...
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The American review of respiratory disease, 1976
Concanavalin A-nonreactive polysaccharide and 2 concanavalin A-reactive polysaccharides of differing concanavalin A affinities that had been purified from culture filtrates of Mycobacterium tuberculosis were subjected to carbohydrate analysis by gas and gas-liquid chromatography.
Thomas M. Daniel, Akira Misaki
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Concanavalin A-nonreactive polysaccharide and 2 concanavalin A-reactive polysaccharides of differing concanavalin A affinities that had been purified from culture filtrates of Mycobacterium tuberculosis were subjected to carbohydrate analysis by gas and gas-liquid chromatography.
Thomas M. Daniel, Akira Misaki
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Cross-linked derivatives of Concanavalin A
1987Publisher Summary This chapter describes methods for the preparation of covalently cross-linked mono-, di-, and tetravalent Concanavalin A derivatives, which do not undergo subunit exchange. Concanavalin A (Con A) is the most widely used lectin in immunology and cell biology. It activates T lymphocytes, leading to cell division, lymphokine production,
Toshiaki Osawa, Masatoshi Beppu
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