Results 61 to 70 of about 12,215,662 (215)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Construction And Functional Verification Of Prevascularized Cgf/Gelma Composite Matrix

International Dental Journal
Aim or purpose: Vascularization is the key to tissue-engineered organoid construction. In this study, GelMA was used for the modification of concentrated growth factors (CGF), combined with acellular vascular matrix (ACVM)-0.25% human-like collagen I ...
Xuqian Liu, Minhai Nie, Qiuyue Mou
doaj   +1 more source

Comparing osteogenic effects between concentrated growth factors and the acellular dermal matrix

Brazilian Oral Research, 2018
Concentrated growth factor (CGF) is an autogenuous product that contains highly concentrated number of platelets and can be derived from venous blood by selective centrifugation.
Luo Huang, Rui Zou, Jinquan He, Kexiong Ouyang, Zhengguo Piao   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Glycosaminoglycan synthesis and shedding induced by growth factors are cell and compound specific

, 2007
The interactions between growth factors and sulphated glycosaminoglycans (GAG) have been extensively studied. the aim of this study is to investigate if growth factors would show specificity of action on the synthesis and shedding of sulphated GAG, using
Suarez, Eloah R., Mataveli, Fabio [UNIFESP], De Matos, Leandro L., Nohara, Angela S. [UNIFESP], Pinhal, Maria Aparecida da Silva [UNIFESP], Nader, Helena Bonciani [UNIFESP]   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Novel approaches for oroantral communication closure: A literature review

Annales Academiae Medicae Silesiensis
Introduction: Oroantral communication (OAC) and oroantral fistula (OAF) are common complications of maxillary posterior tooth extraction. Although conventional flap techniques remain effective, they are associated with postoperative morbidity, anatomical
Agnieszka Balicz, Aleksandra Warakomska, Jakub Fiegler-Rudol, Piotr Mojżesz, Tadeusz Morawiec   +4 more
doaj   +1 more source

Rheological investigation of manufacturability and injectability of highly concentrated monoclonal antibody formulations [PDF]

, 2014
Highly concentrated protein therapeutics offer a convenient way for subcutaneous (sc) drug administration by the patient him-/herself or a healthcare professional. As the therapy e.g.
Allmendinger, Andrea Martina
core   +1 more source