Results 61 to 70 of about 106,796 (274)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Generalized Concentration-Compactness Principles for Variable Exponent Lebesgue Spaces with Asymptotic Analysis of Low Energy Extremals [PDF]

Mathematics, 2020
In this paper, we prove two generalized concentration-compactness principles for variable exponent Lebesgue spaces and as an application study the asymptotic behaviour of low energy extremals.
Zia Bashir, Juan Luis García Guirao, Adil Siddique, Tareq Saeed   +3 more
openaire   +3 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Concentration-compactness principle for variable exponent spaces and applications

Electronic Journal of Differential Equations, 2010
In this article, we extend the well-known concentration - compactness principle by Lions to the variable exponent case. We also give some applications to the existence problem for the p(x)-Laplacian with critical growth.
Julian Fernandez Bonder, Analia Silva
doaj  

Existence of maximizers for Hardy-Littlewood-Sobolev inequalities on the Heisenberg group [PDF]

, 2013
In this paper, we investigate the sharp Hardy-Littlewood-Sobolev inequalities on the Heisenberg group. On one hand, we apply the concentration compactness principle to prove the existence of the maximizers. While the approach here gives a different proof
Han, Xiaolong
core  

Concentration-compactness at the mountain pass level in semilinear elliptic problems

, 2007
The concentration compactness framework for semilinear elliptic equations without compactness, set originally by P.-L.Lions for constrained minimization in the case of homogeneous nonlinearity, is extended here to the case of general nonlinearities in ...
TIntarev, Kyril
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Ground state solutions for a class of Schrödinger–Poisson–Slater equation with Coulomb–Sobolev critical exponent

Boundary Value Problems
This paper is concerned with the Schrödinger–Poisson–Slater equation involving the Coulomb–Sobolev exponent. We apply the concentration compactness principle and the Pohožaev-type identity to overcome loss of compactness caused by the Coulomb exponent ...
Jingai Du, Pengfei He, Hongmin Suo
doaj   +1 more source