Results 81 to 90 of about 3,531,413 (264)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Uniform Concentration-Compactness for Sobolev Spaces on Variable Domains [PDF]
, 2000 We present a new method for proving existence results in shape optimization problems involving the eigenvalues of the Dirichlet–Laplace operator. This method brings together the γ-convergence theory and the concentration-compactness principle.
Bucur, Dorin
core +1 more source
Electronic Journal of Differential Equations, 2018 In this study, we study a Kirchhoff type problem involving singular and critical nonlinearities. With aid of variational methods and concentration compactness principle, we prove that the problem admits a weak solution.
Chun-Yu Lei, Gao-Sheng Liu
doaj
Boundary Value Problems, 2019 In this paper, we first obtain the existence of solutions for a class of elliptic equations involving critical variable exponents and nonlinear boundary values by the mountain pass theorem and concentration compactness principle.
Yingying Shan, Yongqiang Fu
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2019 In this paper, we study a class of quasilinear elliptic equations with $\Phi$-Laplacian operator and critical growth. Using the symmetric mountain pass theorem and the concentration-compactness principle, we demonstrate that there exists $\lambda_i>0 ...
Xuewei Li, Gao Jia
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Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
A Nonhomogeneous Fractional p-Kirchhoff Type Problem Involving Critical Exponent in ℝN
Advanced Nonlinear Studies, 2017 This paper concerns itself with the nonexistence and multiplicity of solutions for the following fractional Kirchhoff-type problem involving the critical Sobolev exponent:
Xiang Mingqi, Zhang Binlin, Zhang Xia
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Existence of multiple solutions for a quasilinear Neumann problem with critical exponent
Boundary Value Problems, 2018 The main purpose of this paper is to establish the existence and multiplicity of nontrivial solutions for a quasilinear Neumann problem with critical exponent.
Yuanxiao Li, Suxia Xia
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source