Results 101 to 110 of about 3,531,413 (264)
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
The concentration-compactness principle for Musielak-Orlicz spaces and applications
This paper extends the Concentration-Compactness Principle to Musielak-Orlicz spaces, working in both bounded and unbounded domains. We show that our results include important special cases like classical Orlicz spaces, variable exponent spaces, double phase spaces, and a new type of double phase problem where the exponents depend on the solution ...
Bahrouni, Ala Eddine, Bahrouni, Anouar
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Existence of solutions for logarithmic Kirchhoff equation without compactness in $\mathbb{R}^3$
Electronic Journal of Qualitative Theory of Differential EquationsIn this paper, we investigate the logarithmic Kirchhoff-type equation \begin{align*} -\left(a+b\int_{\mathbb R^3}|\nabla u|^2 \mathrm{d}x\right)\Delta u+V(x)u=|u|^{p-2}u\log |u|, \quad x\in\mathbb {R}^3, \end{align*} where $a,b>0$ are constants,
Min Li, Libo Wang, Lihong Bao
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The Concentration-Compactness Principle in the Calculus of Variations. The limit case, Part 1
Revista Matemática Iberoamericana, 1985 After the study made in the locally compact case for variational problems with some translation invariance, we investigate here the variational problems (with constraints) for example in \mathbb R^N where the invariance of
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Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Combined effects of changing-sign potential and critical nonlinearities in Kirchhoff type problems
Electronic Journal of Differential Equations, 2016 In this article, we study the existence and multiplicity of positive solutions for a class of Kirchhoff type problems involving changing-sign potential and critical growth terms.
Gao-Sheng Liu, Liu-Tao Guo, Chun-Yu Lei
doaj