Results 61 to 70 of about 3,531,413 (264)

Multiple solutions of a p-Kirchhoff equation with singular and critical nonlinearities

Electronic Journal of Differential Equations, 2017
In this article, we explore the existence of multiple solutions for a p-Kirchhoff equation with the nonlinearity containing both singular and critical terms.
Qin Li, Zuodong Yang, Zhaosheng Feng
doaj  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Doubly Critical Problems Involving Fractional Laplacians in ℝN

Advanced Nonlinear Studies, 2017
In this paper, we show the existence of nontrivial solutions for doubly critical nonlocal elliptic problems in ℝN{\mathbb{R}^{N}} involving fractional Laplacians.
Yang Jianfu, Wu Fengjie
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ground state solutions for asymptotically periodic Schrodinger equations with critical growth

Electronic Journal of Differential Equations, 2013
Using the Nehari manifold and the concentration compactness principle, we study the existence of ground state solutions for asymptotically periodic Schrodinger equations with critical growth.
Hui Zhang, Junxiang Xu, Fubao Zhang
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Normalized solutions for critical Schrödinger equations involving (2,q)-Laplacian [PDF]

Opuscula Mathematica
In this paper, we consider the following critical Schrödinger equation involving \((2,q)\)-Laplacian: \[\begin{cases} -\Delta u-\Delta_{q} u=\lambda u+\mu |u|^{\gamma-2}u+|u|^{2^*-2}u \quad\text{in }\mathbb{R}^N, \\ \int_{\mathbb{R}^N} |u|^{2}dx=a^2,\end{
Lulu Wei, Yueqiang Song
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Multiplicity of solutions to a p-Kirchhoff equation with critical exponent

Boundary Value Problems
In this paper, we consider the following p-Kirchhoff equation: P { [ M ( ∥ u ∥ p ) ] p − 1 ( − Δ p u + | u | p − 2 u ) = λ f ( x , u ) + | u | p ∗ − 2 u in Ω , u = 0 , on ∂ Ω , $$ \left \{ \textstyle\begin{array}{l@{\quad}l} [M(\|u\|^{p})]^{p-1}\left ...
Zhaomin Jiang
doaj   +1 more source