Results 191 to 200 of about 163,087 (265)

Inhibition of EPAC1 Prevents Neuronal Death Mediated by Diesel Exhaust Particles in Ferroptotic Cell Death Conditions. [PDF]

Antioxidants (Basel)
Yan H, Zhang L, Manzano-Covarrubias AL, Gadjdjoe PS, Land A, M van der Veen CHJT, Mitchell-Garcia T, Fayyaz HA, Venema M, Åberg C, van der Hart M, Lezoualc'h F, Cheng X, Dolga AM, Schmidt M.   +14 more
europepmc   +1 more source

Comparison of Tissue Preparations to Identify and Phenotype T Cells in Human Colorectal Tumor Tissue

Cytometry Part A, EarlyView.
ABSTRACT Archived patient samples (e.g., formalin‐fixed paraffin embedded (FFPE) tissue blocks, cryoembedded tissue blocks, and frozen whole tissue samples) are a source of immune information for which corresponding patient data is often collected.
Justin F. Tirados, Sonya Fenton, Helen M. McGuire, Joanna M. Roberts, Kirsten A. Ward‐Hartstonge, Roslyn A. Kemp   +5 more
wiley   +1 more source

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel. [PDF]

Commun Biol
Costa F, Ng LCT, Chow SS, Van Petegem F, Accili EA.   +4 more
europepmc   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

Protocol to identify the signaling network of nucleotide second messengers in Shigella sonnei. [PDF]

STAR Protoc
Cui B, Chen X, Wang M, Deng Y.
europepmc   +1 more source

Developing a macroecology for human‐altered ecosystems

Ecography, EarlyView.
Although anthropogenically‐induced ecological disruptions are fundamentally important in defining ecosystem properties, they are largely overlooked by macroecological theory. Anthropogenic disruptions and their effects are generally not comparable to one another, nor to disturbances that are part of natural disturbance regimes.
Erica A. Newman, Mark Q. Wilber, Alexandre Génin, Oriana E. Chafe, Henry F. Houskeeper, Steven Lee, Eric L. Berlow, John Harte   +7 more
wiley   +1 more source

Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells. [PDF]

FASEB Bioadv
Cunnington RH, Singh N, Shafizadeh M, Hanrahan JW, Dakshinamurti S, Chelikani P.   +5 more
europepmc   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Light-activated cAMP signaling controls sodium-driven motility in <i>Vibrio cholerae</i>. [PDF]

Proc Natl Acad Sci U S A
Xu J, Nakamura S, Tomoyose S, Shimabuku R, Tomioka R, Yamashiro T.   +5 more
europepmc   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source