Results 211 to 220 of about 491,712 (299)

Glycolysis-dependent sulfur metabolism orchestrates morphological plasticity and virulence in fungi. [PDF]

Elife
Shah D, Rewatkar N, M A, Gupta S, Mathivathanan S, Biswas S, Varahan S.   +6 more
europepmc   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

Updated Viloxazine Pharmacology: Experiments Establish Norepinephrine Transporter Occupancy and Serotonin 5-HT_2C, 5-HT_2B, and 5-HT₇ Receptor Binding at Therapeutically Relevant Concentrations. [PDF]

Drugs R D
Garcia-Olivares J, Yegla B, Koch J, Yu C, Rubin J.   +4 more
europepmc   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront. [PDF]

Front Pharmacol
Zhang J, Deng X, Lv J, Lu J, Wang L, Wang W, Lei H, Wang Y, Tian J.   +8 more
europepmc   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

In vitro characterization of osteoblasts from craniofacial fibrous dysplasia of bone and their impact on bone homeostasis. [PDF]

Orphanet J Rare Dis
Sergheraert J, Dumortier C, Guillaume C, Laurence S, Bornert F, Gangloff SC, Mauprivez C, Velard F.   +7 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Environmental stress, water inequality, and environmental justice in Palestinian urban areas: a GIS-based assessment of sanitation and infrastructure disparities in the southern West Bank. [PDF]

Environ Health
Nassar N, Al Zabadi H, Chabaane Z.
europepmc   +1 more source

Salt Stress Induces Imbalanced ADI Pathway Gene Expressions in Pediococcus acidilactici Drives Citrulline Accumulation as an Ethyl Carbamate Precursor in Soy Sauce

Food Bioengineering, EarlyView.
ABSTRACT Citrulline is the main precursor of a carcinogen compound ethyl carbamate (EC) in soy sauce. Accumulation of citrulline is mainly related to metabolism of arginine by Pediococcus acidilactici via the arginine deiminase (ADI) pathway during soy sauce fermentation.
Xiaodie Chen, Jiran Zhang, Haoran Chen, Fang Fang   +3 more
wiley   +1 more source