Results 151 to 160 of about 2,052,197 (246)

Bacterial Vaginosis Is Associated With Transcriptomic Changes but Not Higher Concentrations of Cervical Leukocytes in a Study of Women at High Risk for Human Immunodeficiency Virus Acquisition

Michelle C. Sabo, Salwa Sadoon Mustafa, Aparajita Saha, Brenda Oyaro, Tina L. Fiedler, Melissa A. Krueger, Esther Fuchs, Marianne Mureithi, Kishor Mandaliya, Walter Jaoko, Barbra A. Richardson, Sina A. Gharib, David N. Fredricks, Javeed A. Shah, R. Scott McClelland   +14 more
openalex   +2 more sources

Postmortem metabolomics: Correlating time‐dependent concentration changes of xenobiotic and endogenous compounds

, 2020
Lana Brockbals, Sandra N. Staeheli, Thomas Kræmer, Andrea E. Steuer   +3 more
openalex   +1 more source

Koncentracija u sektoru osiguranja u Srbiji: promene u periodu 2011–2020. i njihova dekompozicija (Concentration in Serbian Insurance Sector: 2011–2020 Changes and Their Decomposition)

, 2022
Rajko Bukvić
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

SGLT2 inhibitors preserve serum chloride in non-diabetic CKD: a propensity-matched and LASSO regression analysis. [PDF]

Ren Fail
Matsui M, Kosugi T, Kitamura S, Nishimoto M, Itano A, Yamamoto M, Yabuta H, Oda A, Kawakami M, Tsushima H, Okamoto K, Eriguchi M, Samejima KI, Tsuruya K.   +13 more
europepmc   +1 more source

THE APPEARANCE OF NORADRENALINE AND ADRENALINE AND THE DEVELOPMENTAL CHANGES IN THEIR CONCENTRATIONS IN THE GUT OF THE CHICK [PDF]

, 1979
S Konaka, Hidenori Ohashi, Toshiaki Okada, Tadashi Takewaki   +3 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Results of a Phase 1 Study Assessing the Effect of CIN-102, a Novel Formulation of the Dopamine Receptor Antagonist Domperidone Designed to Treat Gastroparesis, on Cardiac Repolarization in Healthy Volunteers. [PDF]

Clin Pharmacol Drug Dev
Bond M, Murphy B, Doran B, Darpo B, Xue H, Vrishabhendra L, Isaacsohn J.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Association between plasma concentrations of galectin 3, growth differentiation factor 15, soluble suppression of tumourigenicity 2, and cystatin C and clinical parameters and survival in patients with end-stage renal disease undergoing haemodialysis. [PDF]

Amino Acids
Ptak M, Cader-Ptak A, Marcinowska Z, Dziedziejko V, Safranow K, Kwiatkowska E, Ciechanowski K, Pawlik A, Domański L.   +8 more
europepmc   +1 more source