Results 171 to 180 of about 4,717,932 (275)

The impact of dynamic reversal potential on the evolution of action potential attributes during spike trains. [PDF]

Front Comput Neurosci
Aldohbeyb AA, Vigh J, Lear KL.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dynamic change in bacterial colony concentration during burn surgery and its influencing factors

Huli yanjiu
ObjectiveTo analyze dynamic change in bacterial colony concentration during burn surgery and to explore its influencing factors.MethodsA total of 206 burn wound repair surgeries performed in 3 class Ⅲ clean operating rooms at People's Hospital of ...
GUO Zifei, SHI Wenli, LIU Lihua, PANG Jing, WANG Jiaojiao, LI Qiaoqiao, ZHANG Li   +6 more
doaj  

Concentration-dependent mutational scanning probes the cellular folding landscape of α-synuclein in yeast. [PDF]

Protein Sci
Noh D, Newberry RW.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Long-term prognostic impact of in-hospital serum albumin concentration changes in patients hospitalised for heart failure. [PDF]

Open Heart
Fukino K, Miyata S, Ide T, Matsushima S, Tohyama T, Enzan N, Tsutsui H, Nakamura F.   +7 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

DNA Persistent Length in Solutions of Different pH. [PDF]

Int J Mol Sci
Kasyanenko N, Khansetsen B, Baryshev A, Sokolov P.   +3 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Change in arginine vasopressin concentrations with age

Clinical Chemistry, 1993
G A, Crawford, A G, Johnson, A Z, Gyory, D, Kelly   +3 more
openaire   +2 more sources