Results 71 to 80 of about 10,129,845 (242)
A Supplement to the President's Budget for Fiscal Year 2011
, 2011 Annual report of the U.S. Climate Change Science Program documenting activities and research, goals for the upcoming year, proposed budget considerations, and other information about the organization for fiscal year ...
Climate Change Science Program (U.S.)
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
U.S. National Climate Change Assessment
, 2014 The report summarizes the science of climate change and the impacts of climate change in the United States, now and in the ...
Yohe, Gary W. +3 more
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CHANGE IN THE CONCENTRATION OF BUSINESS ACTIVITIES IN THE REGIONS OF BULGARIA
Trakia Journal of SciencesThe aim of the article is to bind the changes concerning business activity, foreign direct investment and internal migration of the population. The research period is 15 years.
P. Atanasova
doaj +1 more source
RNA-based cooperative protein labeling that permits direct monitoring of the intracellular concentration change of an endogenous protein. [PDF]
Nucleic Acids Res, 2021 Pe KBA +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The determinants of urban concentration [PDF]
Urban concentration differs across countries. One determinant of these differences is economic development, which first increases and subsequently decreases urban concentration.
Junius, Karsten
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The National Global Change Research Plan 2012-2021: A Triennial Update
, 2017 This report is the third triennial update of the National Global Change Research Plan based on scientific research from 13 Federal agencies. The purpose of each update is to "advance science, inform decisions, conduct...assessments" and communicate ...
U.S. Global Change Research Program
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source