Results 51 to 60 of about 7,072,566 (293)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Socioeconomic inequality in financial hardship in accessing quality healthcare services in Ethiopia: a community-based cross-sectional study

Frontiers in Public Health
BackgroundThe 2030 Agenda for Sustainable Development aims to ensure that no one is left behind in health. However, the high magnitude of catastrophic health expenditure (CHE) and impoverishing health expenditure (IHE) remain global challenges.
Yawkal Tsega, Zelalem Birhan, Kidist Adamu   +2 more
doaj   +1 more source

Equitable psychiatry, telehealth, and the COVID-19 pandemic: Analysis of national data

Frontiers in Public Health, 2023
BackgroundAt the beginning of the COVID-19 pandemic, it was foreseen that the number of face-to-face psychiatry consultations would suffer a reduction.
Thomas Yeatman, Thomas Yeatman, Joanne Enticott, Joanne Enticott, Vinay Lakra, Vinay Lakra, Graham Meadows, Graham Meadows, Graham Meadows, Graham Meadows, Graham Meadows   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Socioeconomic Gradient of Obesity in Ireland [PDF]

Using the nationally representative Slan dataset we calculate concentration indices for the incidence of obesity for men and women. We finder higher concentration indices for women than for men, but we also find that concentration indices fell between ...
David Madden
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Engel Elasticities Derived from Lorenz and Concentration Curves: Case of Latvia

Lithuanian Journal of Statistics, 2011
Using information from a household budget survey of the Central Statistical Bureau of Latvia and with thehelp of the estimation of Lorenz curves of total consumption expenditure and consumption expenditure concentration curvesof separate groups of goods,
Ilze Balode
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Modeling the Measurements of the Determinants of ICT Fluency and Evolution of Digital Divide Among Students in Developing Countries—East Africa Case Study

Applied Sciences, 2020
During the last decade, information and communication technology has brought remarkable changes to the education style of developed countries, especially in the context of online learning materials accessibility.
Jean-Pierre Niyigena, Qingshan Jiang, Djemel Ziou, Ruey-Shiang Shaw, A S M Touhidul Hasan   +4 more
doaj   +1 more source