Results 121 to 130 of about 4,047,389 (301)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Strain Concentration Ratio Analysis of Different Waterproofing Materials during Concrete Crack Movement. [PDF]

Materials (Basel), 2021
Oh KH, Kim SY.
europepmc   +1 more source

Magnetic impurity transition in a 'd+s'-wave superconductor

, 2009
We consider the superconducting state of $d+s$ symmetry with finite concentration of Anderson impurities in the limit $\Delta_s/\Delta_d \ll 1$. The model consists of a BCS-like term in the Hamiltonian and the Anderson impurity treated in the self ...
Borkowski, L. S.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Small pilot study of ultra-high pressure reverse osmosis technology for treating landfill leachate in Northwest China

Gongye shui chuli
Landfill leachate has high COD, ammonia nitrogen and conductivity, these complex pollution characteristics make the reverse osmosis treatment load too high, which further leads to the decrease of membrane performance and membrane permeate flux.
ZHANG Huixiang, ZHANG Xuemin, SUN Sanxiang, LI Li   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Performance Simulation and Optimization of Cylindrical Mirror-Spliced Parabolic Trough Solar Collector

Applied Sciences
This paper proposes a new type of solar trough collector with a spliced cylindrical mirror and develops a new ray-tracing method to predict and optimize its performance.
Bowen Liu, Vian Mbabazi, Weidong Huang
doaj   +1 more source

Association between urinary N-acetyl-β-glucosaminidase activity-urinary creatinine concentration ratio and risk of disability and all-cause mortality. [PDF]

PLoS One, 2022
Tanaka SI, Fujioka Y, Tsujino T, Ishida T, Hirata KI.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Isotherm and Electrochemical Properties of Atrazine Sensing Using PVC/MIP: Effect of Porogenic Solvent Concentration Ratio. [PDF]

Membranes (Basel), 2021
Che Lah NF, Ahmad AL, Low SC, Zaulkiflee ND.   +3 more
europepmc   +1 more source