Results 91 to 100 of about 10,506,870 (352)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

An Application of Crystal Plasticity to predict Forming Limit Curve of Dual-Phase Steels with Validation [PDF]

MATEC Web of Conferences
In this paper an alternative approach for generating Forming Limit Curve (FLC) of a Dual-Phase (DP800) steel is presented and validated. Investigation was performed using a rate-dependent crystal plasticity (CP) framework solved through a spectral solver
Venkata Kiranmayi Abburi, Uppaluri Rohith, Pilthammar Johan, Gutkin Renaud   +3 more
doaj   +1 more source

From sugars to FDCA: a techno-economic assessment using a design concept based on solvent selection and carbon dioxide emissions

, 2021
Amir Al Ghatta, James D. E. T. Wilton‐Ely, Jason P. Hallett   +2 more
openalex   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Modelling the economic impact of substandard uterotonics on postpartum haemorrhage in Nigeria: safeguarding medicine quality can reduce costs and contribute towards universal health coverage

BMJ Public Health
Introduction Little evidence exists on the economic threat that substandard uterotonics pose to postpartum haemorrhage (PPH), maternal mortality, and national health systems.
Ahmet Metin Gülmezoglu, Sachiko Ozawa, Sara Rushwan, Yi-Fang Ashley Lee, Colleen R Higgins, Petra Procter, Chimezie Anyakora, Lester Chinery   +7 more
doaj   +1 more source

The Metals in the Biological Periodic System of the Elements: Concepts and Conjectures [PDF]

, 2016
Wolfgang Maret
openalex   +1 more source

Carbonate-silicate cycle predictions of Earth-like planetary climates and testing the habitable zone concept [PDF]

, 2020
Owen Lehmer, David C. Catling, Joshua Krissansen‐Totton   +2 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source