Results 121 to 130 of about 4,198,885 (319)

"Too inhuman": The Destabilization of Empire in Woolf\u27s The Voyage Out*

open access: yes, 2014
Applying Bruno Latour\u27s understanding of Actor-Network Theory (ANT) to Virginia Woolf\u27s novel The Voyage Out, this paper argues that the non-human in the novel consistently act as Latourian mediators, impacting networks as much as, if not more than,

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Boys Will Be Boys: Constructions of Toxic Masculinity in Dramatic, Metaphorized, and Real-Life War Spaces

open access: yes, 2020
This essay uses Shakespeare\u27s Coriolanus and 1 Henry IV, real-life war, and the metaphorized war of the National Football League to explore how the physical landscape of the battlefield functions as a performance area in which toxic ...

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Whole-genome sequencing of Lassa virus from dry blood spots: a comparative evaluation

open access: yesInfectious Diseases of Poverty
Background Whole blood samples are often used to generate whole genome sequences, which provide valuable insights into the genetic make-up of viruses.
Umaru Bangura   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

open access: yesAdvanced Science
Age‐related male hypogonadism is often associated with obesity‐related metabolic disorders and impaired regulation of the testicular anti‐inflammatory microenvironment.
Zhendong Zhu   +10 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

1504 Epithelial to mesenchymal transition (EMT) can be driven by macrophages through multiple signalling pathways

open access: yesJournal for ImmunoTherapy of Cancer, 2023
Darryl Turner   +4 more
doaj   +1 more source

State Sovereignty: Concept and Conceptions

open access: yesInternational Journal for the Semiotics of Law - Revue internationale de Sémiotique juridique
AbstractThe terms “sovereignty” and “state” are used very loosely in scholarly literature. “State sovereignty” is central to many scholarly disciplines and controversial real case scenarios, including territorial disputes; pandemics; arms, drug and human trafficking; terrorism; and the flow of refugees.
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

The Flint Water Crisis: A Narrative with Administrative Recommendations*

open access: yes, 2017
The Flint Water Crisis is a true governmental failure, defined by environmental safeguards left ignored and systemic breakdowns at all levels of regulatory intervention. Though the water itself is certainly the catalyst of this disaster the current state

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