Results 131 to 140 of about 4,198,885 (319)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2012 This paper analyzes two Philadelphia murals, collectively known as The Healing Walls, as significant sites of public discourse through the lens of social constructionism.
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
“Marriage is the tomb of trust and love”: Marriage and Divorce in Olympe de Gouges’ Plays
, 2018 Among female authors and activists of the French Revolution, Olympe de Gouges stands out as one of the most prolific writers who advocated for the extension of full rights to women.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2019 In a play of divided lands and language, Sarah John Sally in Brian Friel’s Translations presents a unique bifurcation; somewhere between character and caricature, aisling and invalid, the actor performing Sarah must tread a delicate balance between ...
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
“And down now, down…”: the Wildernesses of “Burning Chrome” and Inception
, 2018 The portrayal of cyberspace in William Gibson’s 1982 short story “Burning Chrome” reflects the American Gothic conception of the wilderness as both a space of nightmare and wonder.
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How Urban Sustainable Development Can Improve Tourism Attractiveness
ARA: Revista de Investigación en Turismo, 2019 This paper investigates the role of sustainable development in city tourism attractiveness. A tripartite theoretical model of tourism attractiveness was tested to verify the relevance of the economic, environmental, social and cultural aspects of urban ...
Maryse Boivin, Georges A Tanguay
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