Results 131 to 140 of about 10,506,870 (352)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Whole-genome sequencing of Lassa virus from dry blood spots: a comparative evaluation

Infectious Diseases of Poverty
Background Whole blood samples are often used to generate whole genome sequences, which provide valuable insights into the genetic make-up of viruses.
Umaru Bangura, Christopher Davis, Andreas Dahl, Sylvia Klemroth, Emma Thomson, N.’Faly Magassouba, Elisabeth Fichet-Calvet   +6 more
doaj   +1 more source

The Lixiscope concept [PDF]

A portable X-ray imagery instrument which utilizes a converter phosphor or scintillator to convert the X-ray image into visible light image is described.
Yin, L. I.
core   +1 more source

Concepts and Conceptions of Art

The Nordic Journal of Aesthetics, 1993
 
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

State Sovereignty: Concept and Conceptions

International Journal for the Semiotics of Law - Revue internationale de Sémiotique juridique
AbstractThe terms “sovereignty” and “state” are used very loosely in scholarly literature. “State sovereignty” is central to many scholarly disciplines and controversial real case scenarios, including territorial disputes; pandemics; arms, drug and human trafficking; terrorism; and the flow of refugees.
openaire   +2 more sources

New and emerging concepts in the evolution and function of plant biosynthetic gene clusters

, 2021
Guy Polturak, Zhenhua Liu, Anne Osbourn
openalex   +1 more source

Concepts to Reveal Parvovirus–Nucleus Interactions [PDF]

, 2021
Salla Mattola, Satu Hakanen, Sami Salminen, Vesa Aho, Elina Mäntylä, Teemu O. Ihalainen, Michael Kann, Maija Vihinen‐Ranta   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Vermi-remediation of Heavy Metal-Contaminated Soil

Journal of Health and Pollution, 2013
Background. Rapid development in India has lead to pollution around industrial facilities. Earthworms are tolerant of many contaminants, and some are reported to remove heavy metals and pesticides from soil via tissue accumulation.
Suneet V. Dabke, PhD
doaj   +1 more source