Results 131 to 140 of about 10,028,549 (330)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

1504 Epithelial to mesenchymal transition (EMT) can be driven by macrophages through multiple signalling pathways

open access: yesJournal for ImmunoTherapy of Cancer, 2023
Darryl Turner   +4 more
doaj   +1 more source

Déterminants de la transformation structurelle en Afrique

open access: yesRevue Marocaine des Sciences Agronomiques et Vétérinaires, 2020
Cet article examine la contribution de la transformation structurelle à l’accroissement de la productivité du travail en Afrique ainsi que ses déterminants. L’analyse porte sur les données de la période 1991-2017 couvrant 37 pays du continent.
Benoit GBEMENOU   +2 more
doaj  

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