Results 161 to 170 of about 2,509,605 (319)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A Standardized Semantic Feature Norm for 954 Cantonese Concepts. [PDF]

Sci Data
Zhong J, Kang K, Huang W, Zhao Z, Zhang H.   +4 more
europepmc   +1 more source

The Concept of Privacy and the Malay Dwelling Interior Space Planning

, 2013
Noorul Huda Mohd Razali, Anuar Talib
openalex   +1 more source

Request for Paternalism: The Concept and Value of State in the Minds of Russian Youth

, 2023
T. V. Evgenyeva, Antonina V. Selezneva, Nikolay S. Skipin, Dinara D. Tulegenova   +3 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Exnovation: A Concept Analysis. [PDF]

Nurs Open
Nashwan AJ, Joy GV, Mannethodi K, Kunjavara J, Alhalaiqa F, Alomari AMA, Abujaber AA.   +6 more
europepmc   +1 more source

Effect of Concept Mapping Teaching Approach on Students’ Academic Performance in Chemistry in Senior Secondary Schools

, 2022
Torpev Terver Francis, Salaudeen Jaleel Baba   +1 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

An interpretable model based on concept and argumentation for tabular data. [PDF]

Sci Rep
Chi H, Wang D, Liao B, Cui G, Mao F.
europepmc   +1 more source

Determining students' reflective thinking levels and examining their reflections on science concepts

, 2021
Serhan Bozan
openalex   +1 more source