Results 41 to 50 of about 4,198,885 (319)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
World Journal of Education and Humanities, 2019 It gives Prof. Zhiyong Dong’s own definition of the concept of concept.
openaire +2 more sources
The concept ‘indistinguishable’ [PDF]
Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics, 2020 The concept of indistinguishable particles in quantum theory is fundamental to questions of ontology. All ordinary matter is made of electrons, protons, neutrons, and photons and they are all indistinguishable particles. Yet the concept itself has proved elusive, in part because of the interpretational difficulties that afflict quantum theory quite ...
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Journal of the Dow University of Health Sciences, 2018 Objective: To determine the semen profile of male partner of infertile couples coming for treatment of infertility in a private infertility clinic of metropolitan city of Pakistan.
Qurat ul Aman Siddiqui +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Modeling the economic and health impact of substandard uterotonics in Senegal
BMC Pregnancy and ChildbirthBackground Maternal mortality due to postpartum hemorrhage (PPH) remains a global concern especially in low- and lower-middle income countries. PPH is preventable with quality-assured uterotonics.
Yi-Fang Ashley Lee +6 more
doaj +1 more source