Results 81 to 90 of about 10,028,549 (330)
BiomedicinesBackground and Objectives: Cardiovascular disease (CVD) remains a major public health issue worldwide, disproportionately affecting socioeconomically disadvantaged populations due to the social determinants of health (SDOHs).
Andreea Dumitrescu +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
An assessment of trace metal pollution indicators in soils around oil well clusters
Petroleum Research, 2022 Due to the metallic ion constituents of crude oil, environmental levels of toxic metals are often exacerbated when oil is spilt. Biseni community plays host to numerous oil production companies in Bayelsa state, Nigeria.
Aigberua Omozemoje Ayobami
doaj
An Application of Crystal Plasticity to predict Forming Limit Curve of Dual-Phase Steels with Validation [PDF]
MATEC Web of ConferencesIn this paper an alternative approach for generating Forming Limit Curve (FLC) of a Dual-Phase (DP800) steel is presented and validated. Investigation was performed using a rate-dependent crystal plasticity (CP) framework solved through a spectral solver
Venkata Kiranmayi Abburi +3 more
doaj +1 more source
Mind & Language, 2019 AbstractConcepts are our tools for thinking. They enable us to engage in explicit reasoning about things in the world. Like physical tools, they can be more or less good, given the ways we use them—more or less dependable for categorisation, learning, induction, action‐planning, and so on.
openaire +4 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
BMJ Public HealthIntroduction Little evidence exists on the economic threat that substandard uterotonics pose to postpartum haemorrhage (PPH), maternal mortality, and national health systems.
Ahmet Metin Gülmezoglu +7 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?
Frontiers in ImmunologyChronic inflammatory skin diseases are multifactorial diseases that combine genetic predisposition, environmental triggers, and metabolic disturbances associated with abnormal immune responses.
Laure Migayron +6 more
doaj +1 more source