Results 81 to 90 of about 14,451,026 (391)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Brentano’s Concept of Intentional Inexistence [PDF]

, 2006
What Brentano meant by ‘intentional inexistence’ is explained, as is Brentano’s change of mind about this notion. It is only when we understand the metaphysical and methodological assumptions lying behind Brentano’s original doctrine that we can ...
Crane, Tim
core  

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Experimentation in the vineyard of an insurance protocol to cover the harvest’s risk of damage due to cryptogamic diseases linked to the reduction of phytosanitary inputs [PDF]

BIO Web of Conferences, 2022
Raynal M., Davadan L., Lely D., Magot C., Gizardin F., Taillée M., Robichon G.   +6 more
doaj   +1 more source

Cardiovascular Risk Factors in Socioeconomically Disadvantaged Populations in a Suburb of the Largest City in Western Romania

Biomedicines
Background and Objectives: Cardiovascular disease (CVD) remains a major public health issue worldwide, disproportionately affecting socioeconomically disadvantaged populations due to the social determinants of health (SDOHs).
Andreea Dumitrescu, Gabriela Mut Vitcu, Svetlana Stoica, Septimiu Radu Susa, Emil Robert Stoicescu   +4 more
doaj   +1 more source

Vibrating ribbon bolometer: A concept [PDF]

, 1972
Incident electromagnetic radiation pulses maintain bolometer's sensitive element in state of resonant oscillation and correlate amplitude of oscillation with incident radiation power.
Dimeff, J.
core   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

An Application of Crystal Plasticity to predict Forming Limit Curve of Dual-Phase Steels with Validation [PDF]

MATEC Web of Conferences
In this paper an alternative approach for generating Forming Limit Curve (FLC) of a Dual-Phase (DP800) steel is presented and validated. Investigation was performed using a rate-dependent crystal plasticity (CP) framework solved through a spectral solver
Venkata Kiranmayi Abburi, Uppaluri Rohith, Pilthammar Johan, Gutkin Renaud   +3 more
doaj   +1 more source