Results 81 to 90 of about 2,145,870 (224)
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
I.—Alleged Self-Contradictions in the Concept of Relation —A Criticism of Mr. Bradley's “Appearance and Reality,” Pt. I, Ch. III [PDF]
, 1902 G. F. Stout
openalex +1 more source
MCCE: Missingness-aware Causal Concept Explainer [PDF]
arXivCausal concept effect estimation is gaining increasing interest in the field of interpretable machine learning. This general approach explains the behaviors of machine learning models by estimating the causal effect of human-understandable concepts, which represent high-level knowledge more comprehensibly than raw inputs like tokens.
arxiv
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Towards Robust and Reliable Concept Representations: Reliability-Enhanced Concept Embedding Model [PDF]
arXivConcept Bottleneck Models (CBMs) aim to enhance interpretability by predicting human-understandable concepts as intermediates for decision-making. However, these models often face challenges in ensuring reliable concept representations, which can propagate to downstream tasks and undermine robustness, especially under distribution shifts.
arxiv
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
On the Concept Trustworthiness in Concept Bottleneck Models [PDF]
arXivConcept Bottleneck Models (CBMs), which break down the reasoning process into the input-to-concept mapping and the concept-to-label prediction, have garnered significant attention due to their remarkable interpretability achieved by the interpretable concept bottleneck.
arxiv