Results 51 to 60 of about 16,921 (300)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Generalize and Blend: Concept Blending Based on Generalization, Analogy, and Amalgams [PDF]

open access: yes, 2015
The authors acknowledge the financial support of the Future and Emerging Technologies within the 7th Framework Pro- gramme for Research of the European Commission, under FET-Open grant 611553 (COINVENT).
Tarek Richard Besold, Enric Plaza
openaire   +1 more source

BLENDING WITH PURPOSE: THE MULTIMODAL MODEL

open access: yesOnline Learning, 2019
The purpose of this article is to propose a blending with purpose multimodal conceptual model for designing and developing blended learning courses and programs. A blended learning model is presented that suggests teachers design instruction to meet the
Anthony G. Picciano
doaj   +1 more source

Design and Demonstration of a Flying-Squirrel-Inspired Jumping Robot with Two Modes

open access: yesApplied Sciences, 2021
The jumping–gliding robot is a kind of locomotion platform with the capabilities to jump on the ground and glide through the air. The jumping of this robot has to juggle the requirements of initial velocity and posture for entry to gliding and ...
Fei Zhao   +5 more
doaj   +1 more source

Teacher conceptions of blended learning, blended teaching and associations with approaches to design

open access: yesAustralasian Journal of Educational Technology, 2006
<span>This paper describes the results and implications of a qualitative study into teacher conceptions of blended learning, blended teaching and associations of these conceptions with approaches to design for blended learning experiences. Twenty-two teachers from two campus based Australian universities were interviewed and the responses from ...
Robert A. Ellis   +2 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Alternate World Building: Retrofuturism and Retrophilia in Steampunk and Dieselpunk Narratives

open access: yesAnglo Saxonica, 2020
This essay draws on William Gibson and Bruce Sterling’s steampunk and alternate history novel 'The Difference Engine' (1990) and Len Deighton’s dieselpunk and alternate history thriller 'SS-GB' (1978) for the purpose of discussing the blurring of genres ...
Iolanda Ramos
doaj   +1 more source

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