Results 131 to 140 of about 5,397,718 (323)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Adaptive learning on mobile network traffic data

Connection Science, 2019
Machine learning based mobile traffic classification has become a popular topic in recent years. As mobile traffic data is dynamic in nature, the static model has become ineffective for the task of classifying future traffic. This is known as the concept
Zhen Liu, Nathalie Japkowicz, Ruoyu Wang, Deyu Tang   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Handling concept drift in data-oriented power grid operations

Measurement: Energy
Data-oriented business transformation, also known as “digitalization”, can improve business tasks by providing better insights into the subject through the data. In digitalizing the power grid, more accurate state recognition from the measurement data is
Yasushi Miyata, Hiroshi Ishikawa
doaj   +1 more source

Addressing concept drift in reputation assessment [PDF]

In this paper, we address the limitations of existing methods to select representative data for trust assessment when agent behaviours can change at varying speeds and times across a system.
Griffiths, Nathan, Player, Caroline
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Adaptive Buffering Strategies for Incremental Learning Under Concept Drift in Lifestyle Disease Modeling

IEEE Access
Lifestyle diseases such as diabetes manifest through subtle and non-stationary clinical patterns, posing significant challenges for real-time prediction and monitoring.
B. S. Prashanth, M. V. Manoj Kumar, B. H. Puneetha, Nasser Abdo Saif Almuraqab, Ariful Hoque, Immanuel Azaad Moonesar, Ananth Rao   +6 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

UASDAC: An Unsupervised Adaptive Scalable DDoS Attack Classification in Large-Scale IoT Network Under Concept Drift

IEEE Access
Day by day, the number of devices in IoT networks is increasing, and concurrently, the size of botnets in IoT networks is also expanding. Currently, attackers prefer IoT-based botnets to launch DDoS attacks, as IoT devices offer a vast attack surface ...
Saravanan Selvam, Uma Maheswari Balasubramanian   +1 more
doaj   +1 more source