Results 111 to 120 of about 3,595,676 (296)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

DRIFTNET-EnVACK: Adaptive Drift Detection in Cloud Data Streams With Ensemble Variational Auto-Encoder Featuring Contextual Network

IEEE Access
The adoption of cloud computing has been increasingly common across several industries in recent years and offers unparalleled flexibility and scalability in managing computational resources.
Tajwar Mehmood, Seemab Latif, Rabia Latif, Hammad Majeed, Asad Waqar Malik   +4 more
doaj   +1 more source

Nozzle Classification for Drift Reduction in Orchard Spraying: Identification of Drift Reduction Class Threshold Nozzles [PDF]

, 2008
In fruit growing high values of spray drift are found compared to arable field applications. In arable spraying drift reducing nozzles are certified for use as drift reducing measures.
Zande, J.C., van de, Wenneker, M., Holterman, H.J.   +2 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Comprehensive Survey on Concept-Drift-Resilient Network Intrusion Detection Systems

IEEE Access
The evolution of computer networks for service provision, through new devices and architectures, renders past traffic patterns obsolete. The shift in the statistical properties of data is known as concept drift (CD) and is bound to affect automated ...
Mateus Komarchesqui, Vitor Gabriel Da Silva Ruffo, Daniel Matheus Brandao Lent, Vinicius Ferreira Schiavon, Matheus Riki Nakanishi, Gustavo Hideyuki Kitamura Nishikawa, Luiz Fernando Carvalho, Mario Lemes Proenca   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Drift and equilibrium selection with human and computer players [PDF]

The theory of drift (Binmore and Samuelson 1999) concerns equilibrium selection in which second-order disturbances may have first-order effects in the emergence of one equilibrium over the other.
Roberto Ricciuti, Alessandro Innocenti, Mauro Caminati   +2 more
core   +2 more sources

Handling concept drift in data-oriented power grid operations

Measurement: Energy
Data-oriented business transformation, also known as “digitalization”, can improve business tasks by providing better insights into the subject through the data. In digitalizing the power grid, more accurate state recognition from the measurement data is
Yasushi Miyata, Hiroshi Ishikawa
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source