Results 131 to 140 of about 3,595,676 (296)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A New Approach Adapting Neural Network Classifiers to Sudden Changes in Nonstationary Environments [PDF]
, 2017 Business are increasingly analyzing streaming data in real time to achieve business objectives such as monetization or quality control. The predictive algorithms applied to streaming data sources are often trained sequentially by updating the model ...
Amidon, Alexandra
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
IEEE AccessDay by day, the number of devices in IoT networks is increasing, and concurrently, the size of botnets in IoT networks is also expanding. Currently, attackers prefer IoT-based botnets to launch DDoS attacks, as IoT devices offer a vast attack surface ...
Saravanan Selvam +1 more
doaj +1 more source
Concept Drift in Japanese COVID-19 Infection Data. [PDF]
Procedia Comput Sci, 2022 Uchida T, Yoshida K.
europepmc +1 more source
A Model of Evolutionay Drift [PDF]
Drift appears to be crucial to study the stability properties of Nash equilibria in a component specifying different out-of-equilibrium behaviour. We propose a new microeconomic model of drift to be added to the learning process by which agents find ...
Uriarte Ayo, José Ramón
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A Remark on Concept Drift for Dependent Data
Concept drift, i.e., the change of the data generating distribution, can render machine learning models inaccurate. Several works address the phenomenon of concept drift in the streaming context usually assuming that consecutive data points are independent of each other.
Hinder, Fabian +5 more
openaire +4 more sources
Application of a Markov Chain Traffic Model to the Greater Philadelphia Region [PDF]
, 2015 A macroscopic traffic model based on the Markov chain process is developed for urban traffic networks. The method utilizes existing census data rather than measurements of traffic to create parameters for the model.
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source