Results 71 to 80 of about 1,328,254 (307)

L’approche Living Lab : proposition et application d’une démarche méthodologique pour mieux prendre en compte les aspects humains dans la conception de produits logiciels [PDF]

, 2012
Dans cet article, nous décrivons une démarche méthodologique de conception utilisant des technologies émergentes et s’inscrivant dans la continuité de l’approche Living Lab.
LOUP-ESCANDE, Emilie, DANGLADE, Florence, RICHIR, Simon, CHRISTMANN, Olivier   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fear extinction learning improvement in PTSD after EMDR therapy: an fMRI study

European Journal of Psychotraumatology, 2019
Objective: Neurobiological models of Posttraumatic Stress Disorder (PTSD) implicate fear processing impairments in the maintenance of the disorder. Eye Movement Desensitization and Reprocessing (EMDR) is one of the most efficient psychotherapies to treat
Pierre-François Rousseau, Myriam El Khoury-Malhame, Emmanuelle Reynaud, Sarah Boukezzi, Aïda Cancel, Xavier Zendjidjian, Valérie Guyon, Jean-Claude Samuelian, Eric Guedj, Thierry Chaminade, Stephanie Khalfa   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Temporal trends in dengue incidence and mortality across surveillance case classifications: a 13-year analysis from Davao City, Philippines

Frontiers in Tropical Diseases
IntroductionDengue remains a major public health concern in the Philippines, where routine surveillance systems classify reported cases as suspected, probable or confirmed.
Alfredo A. Hinay, Alfredo A. Hinay, Jennifer Ashley H. Reyes, Jennifer Ashley H. Reyes, George Carr G. Plaza   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Virologic Outcomes of Predominantly Tenofovir-Based First-Line Antiretroviral Therapy Among Treatment-Naïve HIV Patients in Davao City, Philippines

Pharmacoepidemiology
Background/Objectives: Tenofovir disoproxil fumarate (TDF)-containing regimens remain the cornerstone of first-line antiretroviral therapy (ART) in many low- and middle-income countries.
Alfredo A. Hinay, Avee Joy B. Dayaganon, Aprilyn F. Francisco-Breva, Jennifer Ashley H. Reyes, Reigner Jay B. Escartin   +4 more
doaj   +1 more source

A method to Formalise the Rapid Prototyping Process [PDF]

, 1999
Facing the increasing complexity of the product design area, (reduction of cycle times, introduction of simultaneous engineering, introduction of digital mock-up, ... ) a research department which wants to define a rapid prototyping process is confronted
AOUSSAT, Améziane, DUBOIS, Patrice, LE COQ, Marc   +2 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source