Results 91 to 100 of about 1,328,254 (307)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
La conception de cours à distance [PDF]
, 2013 Depuis ses débuts, l'enseignement à distance en milieu universitaire a beaucoup évolué. Cette pratique prend d'ailleurs de l'expansion chaque année et de nombreux professeurs sont appelés à créer des cours sous cette forme.
Basque, Josianne, Baillargeon, Marilyn
core +2 more sources
CREATIVE CORE WITHIN THE SCIENTIFIC RESEARCH OF EDUCATIONAL PROBLEMS
Образование и наука, 2015 . The authors continue to explore the issue of practical methodology of research studies (Education and Science No 8, 2014). The aim of the study is to reveal theoretical and practical issues of empirical-research activity at the stages of conceptual ...
Vladimir I. Zagvyazinsky +1 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Predicting the toxicity-efficacy ratio of venetoclax in real-world patients
Annals of HematologyThis study investigates the pharmacokinetic variability and exposure-response relationships of Venetoclax (VEN) in adult patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy.
Loïc Osanno +16 more
doaj +1 more source
COVIDBackground: Breakthrough infections (BTIs) continue to occur among healthcare workers (HCWs) despite full COVID-19 vaccination, raising concerns about ongoing vulnerability in this high-risk group.
Alfredo A. Hinay +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Immaculate Conception Catholic Church, ca. 1920
, 1920 Immaculate Conception Catholic Church in Albuquerque after major renovations to the Church s fa ade overseen by priest Alfonso Mandelari. (Photo courtesy of Immaculate Conception Catholic Church.
Ciotola, Nicholas P.; Immaculate Conception Church (Albuquerque, N.M.)
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source