Results 111 to 120 of about 6,265,653 (300)
Advanced propulsion concepts [PDF]
A variety of Advanced Propulsion Concepts (APC) is discussed. The focus is on those concepts that are sufficiently near-term that they could be developed for the Space Exploration Initiative.
Frisbee, Robert H.
core +4 more sources
Educação & Realidade, 2002 Neste artigo, discute-se o bebê como personagem conceitual, na medida em que foi a partir dele que Gilles Deleuze mostrou, talvez mais profundamente, a incrível confusão entre a Vida e o pensamento ou a própria relação da vida imanente com o pensamento ...
Stéfan Leclercq
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Bioreactor design concepts [PDF]
Two parallel lines of work are underway in the bioreactor laboratory. One of the efforts is devoted to the continued development and utilization of a laboratory research system. That system's design is intended to be fluid and dynamic.
Bowie, William
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
AI-Based Vehicle State Estimation Using Multi-Sensor Perception and Real-World Data
SensorsWith the rise of vehicle automation, accurate estimation of driving dynamics has become crucial for ensuring safe and efficient operation. Vehicle dynamics control systems rely on these estimates to provide necessary control variables for stabilizing ...
Julian Ruggaber +2 more
doaj +1 more source
CoRR, 2002 To cope with problems arising in the description of (1) contextual interactions, and (2) the generation of new states with new properties when quantum entities become entangled, the mathematics of quantum mechanics was developed. Similar problems arise with concepts.
Gabora, Liane, Aerts, Diederik
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source