Results 131 to 140 of about 2,817,688 (298)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Educação & Realidade, 2002 Neste artigo, discute-se o bebê como personagem conceitual, na medida em que foi a partir dele que Gilles Deleuze mostrou, talvez mais profundamente, a incrível confusão entre a Vida e o pensamento ou a própria relação da vida imanente com o pensamento ...
Stéfan Leclercq
doaj
EnergiesBattery-electric rail vehicles are a sustainable alternative for diesel-powered vehicles on tracks without catenary. However, the energy demand to heat and cool the cabin limits the vehicle range, and the applied synthetic refrigerants are ...
Steffen Wieser +3 more
doaj +1 more source
State Sovereignty: Concept and Conceptions
International Journal for the Semiotics of Law - Revue internationale de Sémiotique juridiqueAbstractThe terms “sovereignty” and “state” are used very loosely in scholarly literature. “State sovereignty” is central to many scholarly disciplines and controversial real case scenarios, including territorial disputes; pandemics; arms, drug and human trafficking; terrorism; and the flow of refugees.
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Threshold concepts in computer science : a multi-national empirical investigation
, 2008 This chapter describes an ongoing project aimed at empirically identifying threshold concepts in computer science. In a multi-national, multi-institutional study, we have gathered data from both educators and students.
Sanders, Kate +6 more
core +3 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Second IEEE International Workshop on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications, 2003. Proceedings, 2004 Decision making is done in many application areas. Still most studies are done in such fields as economy and production planning. In methodologies used there exists more variation. This paper reviews the decision concepts discussed in the literature. Also some decision models by the author are commented.
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source