Results 111 to 120 of about 2,174,067 (298)

Mathematics, mastery and metacognition: how adding a creative approach can support children in maths [PDF]

, 2017
Background: Children who hold an incremental view of ability show greater perseverance, improved help-seeking skills and are better able to cope with unexpected challenges.
Bonnett, V., Carr, A., Yuill, N.
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Influence of Classroom Learning Environment on Mastery of Number Activity Concepts among Pre-Primary Learners in Kenya

, 2021
Classroom learning environment is one of the key factors that can be used to unlock the potentials of learners to mastery of concepts in pre-primary learning centres in Kenya.
Ondieki, Lydia Gesare
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

CONCEPTS IN PHILOSOPHY—A ROUGH GEOGRAPHY

, 2014
Much recent work on concepts has been inspired by and is developed within the bounds of the representational theory of the mind often taken for granted by philosophers of mind, cognitive scientists, and psychologists alike (see e.g. Margolis and Laurence
Julia Langkau Concepts, Published Christian Nimtz, Julia Langkau, Christian Nimtz, Universität Erlangen   +4 more
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Atlantic waste disposal, Inc. (AWDI) landfill, Waverly, Virginia: Wetlands impact area, cross section A.A.

, 2020
/~_ ·--­' ~e-1 -1 ---~,,I' AMERICAN LAND CONCEPTS 238 B MAIN STREET REISTERSTOWN, MARYLAND 21136 PHONE: (410) 526-2688 Permitted PFO Impact Area 0.94 Acres I ,_, l~ --;.;:ft\. ~'11,•• ,. '4:;'::.,. '-.;:::_ .--. --~ ·~.~:~~:...'..
American Land Concepts; AECOM (Firm);
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Exploring the interplay of innovation competence and chemistry mastery: insights from educational practices and factors of influence

Eclética Química
Innovation competence is a critical skill today, enabling individuals to generate and apply innovative ideas. Its influence on students’ mastery of chemical concepts and the factors shaping this relationship remain underexplored.
Norliyana binti Md. Aris, Nor Hasniza binti Ibrahim, Noor Dayana Binti Abd Halim, Johari bin Surif   +3 more
doaj   +1 more source

Developing Mind Body Hunger Mastery

, 2018
This quest to explore hunger using classic grounded theory was sparked within a dietitian who was hungry for a deeper understanding of her patients. The high rates of overweight and obesity in the United States are alarming and the mind body link with ...
Siri Khalsa-Zemel, Kara Vander Linden
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