Results 91 to 100 of about 173,493,123 (258)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Childhood mourning : a critical evaluation of psychoanalytic views. [PDF]

, 1982
There is dissention among psychoanalysts about mourning in childhood, including the criteria appropriate to define mourning, the intrapsychic processes of mourning, the ways these manifest in grief and the factors affecting the outcome of childhood ...
Smith, Amanda Tweedie
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

NARRATIVAS DA INFÂNCIA: OS SENTIDOS DO BRINCAR E A FORMAÇÃO DE PROFESSORES

Revista Diálogo Educacional, 2007
The objective of the work is to study the concepts of playing during childhood that are revealed in narratives of future teachers of special education.
Katia Regina Moreno Caiado, Carolina Lucenti Pereira   +1 more
doaj  

Children's Use of Everyday Mathematical Concepts to Describe, Argue and Negotiate Order of Turn

Educare, 2014
In this paper expressions that children themselves use to describe relationships between phenomena in the world, is - when placing a mathematical gaze on them- viewed as everyday mathematical concepts.
Mats Bevemyr
doaj   +1 more source

Early childhood portfolios as a tool for enhancing learning during the transition to school [PDF]

, 2009
From 2005-2008 Mangere Bridge Kindergarten in New Zealand carried out a Centre of Innovation research project exploring the transition between early childhood education and school.
Peters, Sally, Carr, Margaret, Rogers, Pat, Smith, Jemma, Hartley, Carol   +4 more
core   +1 more source

A snapshot of substitute early childhood teachers in Sweden and Australia: Differences in training, regulation and quality [PDF]

, 2018
Substitute teachers play an important role within early childhood education. They are expected to take on the roles and responsibilities of working with children and parents when the regular teacher is away.
Bigsten, Airi,, Airi Bigsten, Karlsson, Rauni,, Garvis, Susanne, Rauni Karlsson, Bigsten, Airi, Garvis, Susanne,, Susanne Garvis, Karlsson, Rauni   +8 more
core   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

The communication accretion spiral : a communication process for promoting and sustaining meaningful partnerships between families and early childhood service staff

, 2005
Findings of an investigation of parents' perceptions of early childhood service quality identified limitations in staff-parent communication which inhibit the development of a shared parent and staff approach to children's care and education.
Elliott, Roslyn
core