Results 41 to 50 of about 2,887,430 (312)
Exploring the Philosophical Problems of Artificial Intelligence Based on ERP Experiment
Proceedings, 2020 To study the cognitive process of the human brain in dealing with philosophical issues, for the first time, from the perspective of scientific experiments, the issue of “relationship” in philosophy was verified.
Yuan Yan
doaj +1 more source
The sparse awakens : streaming algorithms for matching size estimation in sparse graphs [PDF]
, 2017 Estimating the size of the maximum matching is a canonical problem in graph analysis, and one that has attracted extensive study over a range of different computational models.
Muthukrishnan, S. +3 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
ActressMAS, a .NET Multi-Agent Framework Inspired by the Actor Model
Mathematics, 2022 Multi-agent systems show great promise in the actual state of increasing interconnectedness and autonomy of computer systems. This paper presents a .NET multi-agent framework for experimenting with agents and building multi-agent simulations.
Florin Leon
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Optimization Design of Automotive Body Stiffness Using a Boundary Hybrid Genetic Algorithm
Machines, 2022 At the conceptual design stage, it is critical to use appropriate structural analysis and optimization methods. The thin-walled beam transfer matrix method (TBTMM) is adopted to establish the mathematical model of the simplified vehicle body-in-white ...
Haolong Zhong +4 more
doaj +1 more source
Conceptual K-Means Algorithm with Similarity Functions [PDF]
, 2005 The conceptual k-means algorithm consists of two steps. In the first step the clusters are obtained (aggregation step) and in the second one the concepts or properties for those clusters are generated (characterization step). We consider the conceptual k-means management of mixed, qualitative and quantitative, features is inappropriate.
Irene Olaya Ayaquica-Martínez +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source