Results 41 to 50 of about 53,870 (265)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
ITEGAM-JETIAActive Noise Cancellation (ANC) began as a theoretical idea in the 1930s and has now spread to include broad uses in consumer electronics, industrial, and automotive industries.
Mustafa Siham Qassab
doaj +1 more source
Conceptual Understanding through Efficient Automated Design of Quantum Optical Experiments
Physical Review X, 2021 Artificial intelligence (AI) is a potentially disruptive tool for physics and science in general. One crucial question is how this technology can contribute at a conceptual level to help acquire new scientific understanding.
Mario Krenn +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
On the Human Role in Generative Art: A Case Study of AI-driven Live Coding
Journal of Science and Technology of the Arts, 2020 The evolution of philosophical views on art is interwoven with trajectories of accelerating technological amelioration. In the emergence of generative algorithms there is a need for making sense of modern technologies that step in a realm previously ...
Antonio Pošćić, Gordan Kreković
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Fuck the Algorithm: Conceptual Issues in Algorithmic Bias
CoRRAlgorithmic bias has been the subject of much recent controversy. To clarify what is at stake and to make progress resolving the controversy, a better understanding of the concepts involved would be helpful. The discussion here focuses on the disputed claim that algorithms themselves cannot be biased.
openaire +2 more sources
Conceptual K-Means Algorithm with Similarity Functions [PDF]
, 2005 The conceptual k-means algorithm consists of two steps. In the first step the clusters are obtained (aggregation step) and in the second one the concepts or properties for those clusters are generated (characterization step). We consider the conceptual k-means management of mixed, qualitative and quantitative, features is inappropriate.
Irene Olaya Ayaquica-Martínez +2 more
openaire +1 more source