Results 41 to 50 of about 373,174 (293)
Conceptual Algorithmic of the Managerial Information Subsystems
Informatica Economica, 2021 The informative role sub-systems of the integrated unitary economic management process are highlighted. Depending on the precedence and subsequence to material activities, their systematization is carried out. At the conceptual level, according to the logic of the solution succession, imposed by the managerial functions realization, within each sub ...
Tudor Stefan LEAHU +2 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Closing the Gap for Pseudo-Polynomial Strip Packing [PDF]
, 2019 Two-dimensional packing problems are a fundamental class of optimization problems and Strip Packing is one of the most natural and famous among them.
Jansen, Klaus, Rau, Malin
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
A Generic Conceptual Model for Risk Analysis in a Multi-agent Based Collaborative Design Environment [PDF]
, 2009 Organised by: Cranfield UniversityThis paper presents a generic conceptual model of risk evaluation in order to manage the risk through related constraints and variables under a multi-agent collaborative design environment.
Qin, S. F., Ruan, J.
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Adaptive Ensemble Biomolecular Simulations at Scale
, 2019 Recent advances in both theory and methods have created opportunities to simulate biomolecular processes more efficiently using adaptive ensemble simulations.
Balasubramanian, Vivek +5 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
AIThe integration of Artificial Intelligence (AI) technologies in students’ lives necessitates the systematic incorporation of foundational AI literacy into educational curricula. Students are challenged to develop conceptual understanding of computational
Konstantinos Karapanos +5 more
doaj +1 more source