Results 61 to 70 of about 373,174 (293)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Faithful Narratives from Complex Conceptual Models: Should Modelers or Large Language Models Simplify Causal Maps?

Machine Learning and Knowledge Extraction
(1) Background: Comprehensive conceptual models can result in complex artifacts, consisting of many concepts that interact through multiple mechanisms.
Tyler J. Gandee, Philippe J. Giabbanelli
doaj   +1 more source

Introductory Students, Conceptual Understanding, and Algorithmic Success [PDF]

Journal of Chemical Education, 1998
It is important for chemical educators to understand that conceptual learning is actually superior to algorithmic learning along a cognitive spectrum. The reason for this is that conceptual learners have a better sense of the context in problems, can distinguish unique features in problems, and can employ more flexible problem solving strategies.
openaire   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Graph-based discovery of ontology change patterns [PDF]

, 2011
Ontologies can support a variety of purposes, ranging from capturing conceptual knowledge to the organisation of digital content and information. However, information systems are always subject to change and ontology change management can pose challenges.
Abgaz, Yalemisew, Javed, Muhammad, Pahl, Claus   +2 more
core   +2 more sources

Detecting Large Concept Extensions for Conceptual Analysis

, 2017
When performing a conceptual analysis of a concept, philosophers are interested in all forms of expression of a concept in a text---be it direct or indirect, explicit or implicit.
C Dutilh Novaes, DJ Chalmers, DM Blei, F Jackson, KL Gwet, S Deerwester, S Haslanger, S Laurence, TL Griffiths, U Fayyad   +9 more
core   +1 more source

Algorithms and conceptual history

Revista de Filosofía de la Universidad de Costa Rica
Este ensayo explora las interrogantes teóricas que surgen de la proliferación de formas de relación social mediadas digitalmente y su impacto en la constelación moderna de conceptos políticos y sociales. Aunque hace tiempo que varias disciplinas han empezado a abordar el impacto de la tecnología digital en sus objetos de estudio, la indagación sobre ...
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Soft thought (in architecture and choreography) [PDF]

, 2012
This article is an introduction to and exploration of the concept of ‘soft thought’. What we want to propose through the definition of this concept is an aesthetic of digital code that does not necessarily presuppose a relation with the generative ...
Parisi, L., Portanova, Stamatia
core