Results 191 to 200 of about 2,272,322 (296)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Conceptual design of the energy-switchable storage ring as a high-brilliance light source over a wide wavelength range. [PDF]

J Synchrotron Radiat
Sato T, Funamori N, Amemiya K, Usami N, Ohigashi T, Kataoka R, Shimizu N, Tanaka H, Nakao H, Yamada Y, Wakabayashi D, Obina T, Adachi M, Kobayashi Y, Shimosaki Y, Tanimoto Y, Tsuchiya K, Harada K, Yamamoto N, Igarashi N.   +19 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Preserving conceptual design integrity: strategies for enhancing interoperability in architectural digital design workflows. [PDF]

Sci Rep
El-Khouly T, Abdelhalim O.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Conceptual design of a decision knowledge service model integrating a multi-agent supply relationship diagram for electric power emergency equipment. [PDF]

Front Big Data
Si J, Liu C, Ye J, Wu J, Wang J, Hu K, Ju C, Cao Q.   +7 more
europepmc   +1 more source

Interactive freehand sketching as the means for online communication of design intent in conceptual design conducted by Brainwriting. [PDF]

Int J Interact Des Manuf, 2021
Rizzuti S, De Napoli L.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

V-CarE-A Conceptual Design Model for Providing COVID-19 Pandemic Awareness: Proposal for a Virtual Reality Design Approach to Facilitate People With Persistent Postural-Perceptual Dizziness.

JMIR Res Protoc, 2023
Zaidi SFM, Shafiabady N, Afifi S, Beilby J.   +3 more
europepmc   +1 more source