Results 201 to 210 of about 329,719 (257)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Design cognition for conceptual design

, 2010
openaire   +2 more sources

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Conceptual design of biosensors

2015 6th International Conference on Information, Intelligence, Systems and Applications (IISA), 2015
Design of biosensors refers to the field of interdisciplinary research, therefore, it is necessary to develop a unified systems approach that is invariant to the physical nature of the used phenomena and processes to create an automated system for conceptual design of such elements.
Irina Petrova 0002, Viktoriya Zaripova, Yuliya Lezhnina, Irina Mitchenko, Vitaliy Sokolskiy   +4 more
openaire   +2 more sources

Design Research as Conceptual Designing: The Manhattan Design Concept

Interacting with Computers, 2015
The term ‘conceptual designing’ refers to an activity that various practitioners already undertake, but for which we lack a clear definition. This article provides that definition and uses an example of a design concept called ‘Manhattan’ to present how exactly this type of process happens.
Jacucci, Giulio, Sellen, Abigail, Harper, Richard, Ylirisku, Salu   +4 more
openaire   +5 more sources

Conceptual Modeling for Design Formulation

Engineering with Computers, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Y.-C. Shen, Piero P. Bonissone, L. J. Feeser   +2 more
openaire   +2 more sources

A conceptual model for design management

Computer-Aided Design, 1996
Abstract Design management is a very important topic for every state-of-the-art cad / cae environment. By definition, the concept of design management addresses a set of functions which build, maintain, display, manage and enforce relationships among the data and among the design tools that are involved in a project.
ZANELLA, Marina, GUBIAN, Paolo
openaire   +2 more sources

Design Ideator: A Conceptual Design Toolbox

Journal of Computing and Information Science in Engineering, 2019
Computer tools for embodiment and detailed engineering design (computer-aided design (CAD)) evolved rapidly in the past 35 years and are now pervasive throughout the industry. But todays commercial CAD is geometry-centric, not appropriate for early stages of design when detailed geometry and dimensions are not known.
S. Narsale, Y. Chen, M. Mohan, Jami J. Shah   +3 more
openaire   +1 more source