Results 101 to 110 of about 6,381,927 (303)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A CONCEPTUAL FRAMEWORK TO ASSESS UNIVERSITY PARTICIPATION IN LIFELONG LEARNING [PDF]
Business Excellence and Management, 2013 Lifelong learning has grabbed the attention of both scholars and practitioners in the last decade and has developed into an orientation embraced by universities from all over the world as creators of knowledge and providers of learning for the knowledge ...
Alina Irina POPESCU
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2021 One of the questions I often get asked is how to develop a Conceptual framework for a thesis outline. Here's the advice I've always given to my graduate students. A framework is simply the structure of a research idea or concept and how it adds up. The conceptual framework develops the research problem in relation to the relevant literature.
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
CONCEPTUAL FRAMEWORK: SUBSIDY TO THE NURSING’S ASSISTENCE
Cogitare Enfermagem, 1998 The historical development of Nursing’s Models and Theories is approached in this paper and it tries to wake up for a discussion about framework, which offers subsidy to the professional practice.
Telma Elisa Carraro
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Frontiers in TuberculosisTuberculosis (TB) is a preventable, curable disease but still impacts people in high-burden countries, who face challenges, including stigma, in accessing and engaging with healthcare services.
Bushra Bibi +5 more
doaj +1 more source