Results 141 to 150 of about 397,590 (315)

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti   +5 more
wiley   +1 more source

Design process knowledge reuse challenges and issues

open access: yes, 2007
Product knowledge support needs are compared in two companies with different production volumes and product complexity. Knowledge support requirements identified include: function, performance data, requirements data, common parts, regulatory ...
Roy, Rajkumar   +4 more
core  

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

open access: yesArthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles   +14 more
wiley   +1 more source

Knowledge and Conceptual Engineering: The Epistemology, Ethics, and Politics of Meaning Production

open access: yes
Suppose you could change people's way of thinking about the world at its very roots, by changing the very concepts by means of which they think. Suppose, further, that this would make the world a better place; that would be quite something. Knowledge and
Simion, Mona, Kelp, Christoph
core  

Determination of Classroom Teachers’ Conceptual Knowledge Levels and Attitudes Towards Education 4.0

open access: yesReports on Geodesy and Geoinformatics
This study aims to investigate the conceptual knowledge levels and attitudes of classroom teachers toward Education 4.0 in the context of primary education in Hatay, Türkiye.
Yaraş Zübeyde   +2 more
doaj   +1 more source

Minimal Important Change and Minimal Clinically Important Difference in Pain and Function With Exercise in Hip Osteoarthritis

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to estimate the minimal important change (MIC) and minimal clinically important difference (MCID) for pain and physical function in individuals with hip osteoarthritis (OA) following a physiotherapist‐guided exercise intervention.
Yareni Guerrero   +8 more
wiley   +1 more source

Knowledge-based cost modelling for innovative design [PDF]

open access: yes, 2000
The contribution to new knowledge from this research is a novel method for modelling production costs throughout the design phase of a product's lifecycle, from conceptual to detail design. The provision of cost data throughout the design phase allows
Rehman, S.
core  

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns   +2 more
wiley   +1 more source

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