Results 151 to 160 of about 24,842,000 (395)

Conceptual Ideas and Orientators of the Nothern American Model of Adult Education [PDF]

open access: yes, 2019
The article deals with conceptual ideas and orientators of Northern American model of adult education. It is substantiated, that Nothern American model of adult education is based on the following philosophical directions: liberalism, progressivism ...
Terenko, O. (Olena)
core  

Presenting of change management model for copper industries with HSE approach using FAHP and DEMATEL

open access: yesSalāmat-i kār-i Īrān, 2020
Background and Aims: management of change is one of the requirements of quality standards  in dynamic industries. Make changes without evaluation can be a challenge, if not managed properly, can be irreparable damage.
Manouchehr Omidvari   +2 more
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Towards a unified conceptual model representation [PDF]

open access: yes, 2007
A good documentation or representation is important for communicating simulation conceptual models between stakeholders effectively. A good conceptual model representation may be used as a legal document in a simulation project contract; it may be used ...
Onggo, B S S
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Raster graphics extensions to the core system [PDF]

open access: yes
A conceptual model of raster graphics systems was developed. The model integrates core-like graphics package concepts with contemporary raster display architectures.
Foley, J. D.
core   +1 more source

Explaining the Effects of Climate Elements in Tehran’s Metropolis Air Quality

open access: yesتحقيقات جغرافيايی, 2018
Introduction and Background Atmospheric pollutants are elements whose high concentrations cause damage to the Earth’s biological cycles, and its concentration is usually determined by concentrations of air pollutants such as nitrogen dioxide, sulfur ...
nabi allah ramezani   +2 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Modified Stage-Gate: A Conceptual Model of Virtual Product Development Process [PDF]

open access: yes, 2009
In today’s dynamic marketplace, manufacturing companies are under strong pressure to introduce new products for long-term survival with their competitors.
Ahmed, Shamsuddin   +2 more
core   +4 more sources

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