Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Potential Mechanisms of Influence Between Spiritual Practices and Cognitive Health: A Systematic Review and Conceptual Model. [PDF]
Brain SciBritt KC +7 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Linking Supply Chain Performance, Supply Chain Resilience, and Organizational Recovery Capability: A Proposed Conceptual Model [PDF]
Kok Beng Loh, Cheng Ling Tan
openalex +1 more source
VR Road and Construction Site Safety Conceptual Modeling Based on Hand Gestures [PDF]
, 2019 Stéphane Côté, Olivier Beaulieu
openalex +1 more source
Navigating Person-Centred Nutrition and Mealtime Care in Rehabilitation: A Conceptual Model. [PDF]
J Hum Nutr DietOlufson HT +3 more
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Employee Performance at Workplace: Conceptual Model and Empirical Validation
, 2017 R. K. Pradhan, L. K. Jena
semanticscholar +1 more source
Conceptual Diagnostics for Knowledge Graphs and Large Language Models [PDF]
Ricardo Sosa +3 more
openalex +1 more source